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Structure and stability of phycocyanin from thermotolerant Oscillatoria

Year: 2025
Type: article
Abstract: Phycocyanin (PC), a pigment-protein complex with diverse biotechnological applications, plays a key role in light energy transfer for photosynthesis in cyanobacteria. PC (O-PC) from a thermotolerant cyanobacteria Oscillatoria sp. N09DM exhibits remarkable stability compared to its mesophilic counterparts, making it highly valuable for industrial and medical applications. To understand the basis of its stability, the crystal structure of O-PC is solved and analysed. Structural analysis reveals a key molecular interaction, including hydrogen bonds, salt bridges and hydrophobic interactions, along with amino acid substitutions that provide the thermal stability. Additionally, structural results provide insights into chromophore-protein interactions for understanding O-PC's role in the efficient transfer of light energy.
Source: FEBS Letters
DOI: 10.1002/1873-3468.70048
Authors: Stuti N. Patel, Ravi R. Sonani, Gagan D. Gupta, Niraj Kumar Singh, Chandni Upadhyaya, Bhargavi Sonavane, Seema Amin, Vinay Kumar, Datta Madamwar
Institutions: Charotar University of Science and Technology, Bhabha Atomic Research Centre, University of Virginia, Government of Gujarat, Gujarat Biotechnology Research Centre, Sardar Patel University
Language: English
Open Access status: green
OpenAlex ID: W4409951265
FWCI: 0.783
Cites: 45
Cited by: 3
Related to: 10