Work

RYR2 as new target for antiarrhythmic therapy: Harnessing the power of existing chemical entities for drug discovery

Year: 2025

Type: article

Abstract: The intracellular calcium release channel ryanodine receptor type 2 (RyR2) plays an essential role in the cardiac excitation-contraction coupling. Hyperactive RyR2 calcium channels caused by gain-of-function mutations or posttranslational modifications in structural heart disease have been linked to atrial and ventricular arrhythmias. We review new RyR2 inhibitors and their use as antiarrhythmic drugs in animal models of ventricular arrhythmias.

Source: Heart Rhythm

DOI: 10.1016/j.hrthm.2025.03.1883

Authors: Tri Q. Do, Björn C. Knollmann

Institutions: Vanderbilt University, Vanderbilt University Medical Center

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,790