Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Mycoprotein, a filamentous fungi-based protein substitute for traditional meat products, plays a crucial role in ensuring global food security. While genetic manipulation of mycoprotein-producing fungi holds promise for improving key traits, such as higher protein content and biomass yield, substantial progress has yet to be made. In this study, we investigated the function of genes related to conidiogenesis to identify valuable genetic elements for increasing fungal biomass yields in Fusarium venenatum . In the FvFLBD knockout mutant of F. venenatum, fungal biomass increased compared to the wild-type strain, with conidia formation completely abolished. Nutrient profiling further revealed elevated amino acid content in this mutant, likely due to metabolic changes. Additionally, we observed synergistic effects on biomass yield in the FvFLBD and FvUBQ14 double knockout, suggesting that this approach could serve as a comprehensive strategy for enhancing fungal food production. Our findings provide valuable genetic insights and broaden the horizon of mycoprotein applications in the food industry.
Authors: Hosung Jeon, Soobin Shin, Jessica Winarto, Sohyun Lee, Kyungsu Kang, Dae-Geun Song, Hokyoung Son
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
SDG: Zero hunger
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: G200041619, G3941322544, G3962887504
OpenAlex ID: W4409953974