Work

Rapid and facile one-step microwave synthesis of macrobicyclic cryptands

Year: 2025

Type: article

Abstract: Liquid-assisted grinding (LAG) and microwave synthesis are proposed as alternative routes for the synthesis of cryptands, with reaction times of up to 16 times faster than traditional methods. These rapid and facile techniques have the potential to replace traditional methods for a high-yield formation of clathrochelates, and other materials. The cryptand 6,16,25-tribenza-1,4,8,11,14,18,23,27-octaazatricyclo[9.9.9]nonacosa-4,7,14,17,23,26-hexaene hexahydrate, C36H42N8·6H2O, (Ph3T2 ) was synthesized using this novel method. The crystal structure was redetermined by single-crystal X-ray diffraction using synchrotron radiation at 120 K. The structure exhibits disorder in the water molecule of hydration.

Source: Acta Crystallographica Section E Crystallographic Communications

DOI: 10.1107/s2056989025003044

Authors: Ulrich Baisch, Marie Christine Scicluna, Liana Vella-Zarb

Institution: University of Malta

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $500

Funders: European Commission, European Regional Development Fund, European Social Fund