Retrospective Study of Modifications in Foveal Choroidal Vessel Diameter and Thickness as Indicators for Retreatment of Polypoidal Choroidal Vasculopathy
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective This study aimed to optimize the retreatment strategy for Polypoidal Choroidal Vasculopathy (PCV) by evaluating changes in Choroidal Vessel Diameter (CVD) and thickness. Methods A retrospective study tracked PCV patients receiving antivascular endothelial growth factor conbercept injections with a 3+PRN regimen for 6 months. Key parameters were recorded at various intervals postinjection and at follow-up's end. Recurrence prediction was based on CVD and choroidal changes. Results 52 patients (54 eyes) diagnosed with PCV were enrolled. 32 eyes (59.2%) showed exudation resolution, forming the resolution group, while 22 eyes (40.7%) formed the non-resolution group. In the resolution group, 18 patients (56.3%) experienced exudation recurrence and underwent retreatment. Best-corrected visual acuity, central retinal thickness, CVD, and CT significantly improved at the 6-month mark. In the resolution group, CVD and CT decreased continuously from baseline to endpoint (p < 0.05), indicating a significant relationship between resolution occurrence and CVD/CT changes. In the recurrence group, CVD and CT (nasal) significantly increased within 1 month before resolution. Conclusion In PCV patients treated with antivascular endothelial growth factor, increased CVD and CT during follow-up visits indicate a potential need for retreatment. Predicting retreatment risk based on CVD and CT changes is crucial for future research in determining retreatment necessity for PCV.
Source: The Open Ophthalmology Journal
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G8444347988, G8764071032
OpenAlex ID: W4409957009