Exploring the Anti-cancer Effect of Ethanol Extract of Jamaican Cherry (Muntingia calabura L.) Leaves on CT26 Colorectal Cancer Cells through WNT Signaling
Year: 2025
Type: article
Abstract: The prevalence rate of mortality in colorectal cancer is comparatively elevated. A standard or effective treatment has not been developed to resolve this issue. Utilizing Muntingia calabura, which is known to contain rutin with anti-cancer properties, is one of the strategies that can be implemented. The present study focuses on the potential therapeutic effects of M. calabura as an anti-cancer agent in colorectal cancer. Specifically, this study investigates the anti-cancer properties of rutin against colorectal cancer. The results of this study showed that the ethanolic extraction of M. calabura contained approximately 0.727 mg/mL of rutin. Additionally, the cytotoxicity assessment revealed that the rutin fraction was moderately cytotoxic, with a value of 70.808 μg/mL. The results of molecular docking experiments demonstrated a high degree of accuracy in predicting the interaction between rutin and β-catenin. Furthermore, the quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay revealed a significant reduction in the expression of the β-catenin gene within the cells exposed to the extract. In conclusion, M. calabura extract exhibits anti-cancer properties by influencing the WNT signaling pathway in CT26 cells.
Source: Majalah Obat Tradisional
DOI: 10.22146/mot.94297
Institution: Universitas Gadjah Mada
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4409957115