Work

Oocytes with aggregates of smooth endoplasmic reticulum may not affect reproductive outcomes in split IVF-ICSI insemination: a retrospective study

Year: 2025

Type: article

Abstract: Objective: To investigate the impact of smooth endoplasmic reticulum aggregates (SERa) in oocytes on embryological outcomes and clinical and neonatal outcomes during split IVF-ICSI cycles. Methods: A retrospective analysis was conducted using clinical data from January 2020 to December 2023 at the Reproductive Medicine Center of Hainan Women and Children's Medical Center. Patients were divided into SERa+ and SERa- cycles based on the visibility of SERa after the removal of cumulus cells. Basic patient characteristics, embryological outcomes, clinical and neonatal outcomes were compared between the two groups. Results: on the day of hCG administration (P<0.01) and a significantly increased number of retrieved oocytes (P<0.01). In terms of embryological outcomes, the total D3 high-quality embryo rate was significantly higher in the SERa+ cycles (P<0.01). There was a significant increase in the D3 high-quality embryo rate for ICSI, but no difference in the D3 high-quality embryo rate for IVF. No significant differences were observed between the SERa+ and SERa- cycles in terms of βhCG positivity rate, clinical pregnancy rate, implantation rate, early miscarriage rate, live birth rate, preterm birth rate, newborn height, and weight (P>0.05). No congenital birth defects were found in either group. Conclusion: fertilization, embryological, clinical, or neonatal outcomes.

Source: Frontiers in Endocrinology

DOI: 10.3389/fendo.2025.1567066

Authors: Yejuan Li, Jiajia Hu, Hui Lu, Zhiyong Lu, Jingjing Zhong, Lisen Shi

Institution: Hainan Maternal and Child Health Hospital

Language: English

Topic: Reproductive Biology and Fertility

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801