Resting State Functional Connectivity Patterns Associate with Alcohol Use Disorder Characteristics: Insights from the Triple Network Model.
Year: 2025
Type: preprint
Study design: Observational Study
Abstract: Prolonged alcohol use results in neuroadaptations that mark more severe and treatment-resistant alcohol use. The goal of this study was to identify functional connectivity brain patterns underlying Alcohol Use Disorder (AUD)-related characteristics in fifty-five adults (31 female) who endorsed heavy alcohol use. We hypothesized that resting-state functional connectivity (rsFC) of the Salience (SN), Frontoparietal (FPN), and Default Mode (DMN) networks would reflect self-reported recent and lifetime alcohol use, laboratory-based alcohol seeking, urgency, and sociodemographic characteristics related to AUD. To test our hypothesis, we combined the triple network model (TNM) of psychopathology with a multivariate data-driven approach, regularized partial least squares (rPLS), to unfold concurrent functional connectivity (FC) patterns and their association with AUD characteristics. We observed three concurrent associations of interest: i) drinking and age-related cross communication between the SN and both the FPN and DMN; ii) family history density of AUD and urgency anticorrelations between the SN and FPN; and iii) alcohol seeking and sex-associated SN and DMN interactions. These findings demonstrate the utility of combining theory- and data-driven approaches to uncover associations between resting-state functional substrates and AUD-related characteristics that could aid in the identification, development, and testing of novel treatment targets across preclinical and clinical models.
Source: PubMed
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Comprehensive White-matter Microstructure-informed Analytical Methods to Elucidate Neurobiological Mechanisms of Sports-related Concussion (SRC), Limbic-Executive Network Transitions in Alcohol Use Disorder, CENTER ON GENETIC DETERMINANTS OF ALCOHOL INGESTION, Functional connectivity reconfigurations in risk for alcohol use disorders, Influence of the College Football Athletes' Cumulative Head Impact Exposure (HIE) on the mTBI incidence and post-mTBI health outcomes, Indiana Clinical and Translational Sciences Institute, Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol
OpenAlex ID: W4409962083