Work

[Catalpol reduces liver toxicity of triptolide in mice by inhibiting hepatocyte ferroptosis through the SLC7A11/GPX4 pathway: testing the Fuzheng Zhidu theory for detoxification].

Year: 2025

Type: other

Abstract: OBJECTIVES: theory for detoxification. METHODS: concentration, lipid peroxidation, ROS level and the ferroptosis-related proteins. RESULTS: level. In HL7702 cells, inhibition of ferroptosis by Fer-1 significantly reversed triptolide-induced elevation of ALT, AST and LDH levels. Western blotting and qRT-PCR demonstrated that catalpol reversed abnormalities in expressions of SLC7A11, FTH1 and GPX4 at both the mRNA and protein levels in triptolide-treated HL7702 cells. CONCLUSIONS: The combined use of catalpol can reduce the hepatotoxicity of triptolide in mice by inhibiting excessive hepatocyte ferroptosis through the SLC7A11/GPX4 pathway.

Source: PubMed

DOI: 10.12122/j.issn.1673-4254.2025.04.16

Authors: Linluo Zhang, Changqing Li, Lingling Huang, Xueping Zhou, Yuanyuan Lou

Institutions: Nanjing University of Chinese Medicine, Jiangsu College of Nursing, Huaian First People’s Hospital, Nanjing Medical University

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4409962248

Cites: 1

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Related to: 10