Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide We have developed a transition-metal-free photocatalytic S–N coupling reaction utilizing sodium organosulfinate and hydroxamic acid to synthesize acylsulfonamides. Employing 2,3,5,6-tetra(9H-carbazol-9-yl)benzonitrile (4CzBN) as a photocatalyst, this method enables the preparation of a wide range of acylsulfonamides from arylhydroxamic acids or N -hydroxycarbamates. Mechanistic studies indicate that the generation of singlet oxygen ( 1 O 2 ) via the Energy Transfer Process (EnT) is crucial for facilitating the reaction. This approach offers a sustainable and efficient pathway for acylsulfonamide synthesis under mild conditions.
Source: Organic Letters
Authors: Long Yin Lam, Cong Ma
Institution: Hong Kong Polytechnic University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W4409962844