Work

Mycobacterium marinum as a model for understanding principles of mycobacterial pathogenesis

Year: 2025

Type: review

Abstract: ABSTRACT Mycobacterium marinum is a fish pathogen that has become a powerful and well-established model that has accelerated our understanding of the mechanisms of mycobacterial disease. M. marinum is a versatile surrogate for understanding the closely related human pathogen M. tuberculosis , which causes tuberculosis in humans. M. marinum has defined key mechanisms of pathogenesis, both shared with M. tuberculosis and unique to this species. In this review, we discuss the discovery of M. marinum as an occasional human pathogen, the shared aspects of pathogenesis with M. tuberculosis, and how M. marinum has been exploited as a model to define the molecular mechanisms of mycobacterial pathogenesis across several phases of infection.

Source: Journal of Bacteriology

DOI: 10.1128/jb.00047-25

Authors: Aruna R. Menon, Rebecca J. Prest, David M. Tobin, Patricia A. Champion

Institutions: Duke University, Duke Medical Center, University of Notre Dame

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases