Improvement of Kidney Function Following Unilateral Nephrectomy in a Patient With Cardiovascular-Kidney-Metabolic (CKM) Syndrome
Year: 2025
Type: article
Study design: Case Report
Abstract: Cardiovascular-kidney-metabolic (CKM) syndrome is a significant contributor to the progressive decline in renal function, often leading to advanced chronic kidney disease. We report a 55-year-old man with a history of obesity, diabetes, and hypertension who was diagnosed with renal cell carcinoma (RCC) and underwent unilateral nephrectomy for his treatment, which led to decreased kidney function. The patient showed signs of improvement in glomerular filtration rate (GFR) and proteinuria after weight loss with combination therapy for CKM, including renin-angiotensin-aldosterone system (RAAS) inhibitors, sodium-glucose cotransporter-2 inhibitors (SGLT-2 inhibitors), and glucagon-like peptide-1 receptor agonists (GLP-1RA).
Source: Cureus
DOI: 10.7759/cureus.83263
Authors: Mrinal Asopa, Mohammad Kamgar, James Wilson, Sina Emami, Brian Shuch, Niloofar Nobakht
Institution: University of California, Los Angeles
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409963548