Japanese Traditional Herbal Medicine (Kampo Medicine) Improved Functional Hypothalamic Amenorrhea With Inherited Antithrombin Deficiency
Year: 2025
Type: article
Study design: Case Report
Abstract: We report a case of a 28-year-old Japanese woman diagnosed with functional hypothalamic amenorrhea (FHA). Although oral estrogen-progestin therapy was initially recommended, laboratory tests revealed an inherited antithrombin (AT) deficiency, which is associated with an increased risk of venous thromboembolism (VTE). To mitigate this risk, we selected Kampo medicine (Japanese traditional herbal medicine) as an alternative treatment for amenorrhea. She was prescribed Keishibukuryogan and Shigyakusan, which led to the resumption of menstruation shortly after initiation. Subsequently, Tokakujokito was added to address persistent constipation, resulting in the regularization of her menstrual cycle and resolution of associated symptoms without adverse effects. This case suggests that Kampo medicine may offer a viable therapeutic alternative for managing menstrual disorders in patients predisposed to thrombosis.
Source: Cureus
DOI: 10.7759/cureus.83237
Authors: Mitsuyuki Takamura, Yukari Nose, Yasuyuki Ota, Mayu Omori
Institution: Mie University Hospital
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409967278