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Gastric cancer or hodgkin lymphoma? Unraveling the diagnostic dilemma of primary gastric classical hodgkin lymphoma

Year: 2025

Type: article

Abstract: Primary gastric classical Hodgkin lymphoma (PGHL) is a primary malignant neoplasm of the stomach, often clinically and radiologically mimicking gastric cancer. Immunohistochemistry is needed to diagnose such rare tumors. A 45-year-old male presented with abdominal pain, nausea, and unintentional weight loss. First investigations, such as endoscopic examination and biopsy, indicated that this was a case of non-Hodgkin lymphoma (HL). However, the immunohistochemistry (IHC) reinforced the classical HL with positive markers of CD15, CD30, PAX5, and MUM1, categorizing it as a mixed cellularity subtype. The patient underwent distal gastrectomy with Billroth II reconstruction and received four cycles of bleomycin, doxorubicin, vinblastine, dacarbazine chemotherapy, leading to complete clinical and radiological remission. PGHL, although rare, should be considered in the differential diagnosis of gastrointestinal malignancies. Immunohistochemistry plays a pivotal role in correct diagnosis, and a combination of surgery and chemotherapy is the ideal treatment strategy, as demonstrated in this case.

Source: International Journal of Molecular and Immuno Oncology

DOI: 10.25259/ijmio_28_2024

Authors: Santhosh Meedimale, Lalatendu Moharana, Swati Sucharita Mohanty, Lipsita Samantaray, Soumya Surath Panda

Institutions: Siksha O Anusandhan University, Institute of Medical Sciences and Sum Hospital

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4409971280

FWCI:

Cites: 18

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Related to: 10