Year: 2025
Type: article
Abstract: The tumor microenvironment (TME) plays a pivotal role in the initiation, progression, and metastasis of breast cancer. Recent advances in microbiome research have unveiled the intricate interactions between microbial communities and host physiology, suggesting that microbial-derived metabolites can significantly influence cancer biology. These small molecules, including short-chain fatty acids (SCFAs), secondary bile acids, polyamines, and tryptophan-derived indoles, serve as biochemical messengers that modulate inflammation, immune responses, angiogenesis, and epithelial-mesenchymal transition (EMT) within the TME. Accumulating evidence indicates that specific microbial signatures are associated with distinct breast cancer subtypes, and their metabolic outputs may either promote or suppress tumorigenesis.
Authors: Farman Ullah, Warda Wajee, Mah Noor, Rabiya Zafar, Laiba Shafiq, Zulqurnain Zulqurnain, Haseeba Khalid, Hammad Mudassar, Shahid Mehmood
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4409972267