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Relationship between exhaled volatile organic compounds and lung function change in idiopathic pulmonary fibrosis

Year: 2025
Type: article
Study design: Observational Study
Abstract: Volatile organic compounds (VOCs) in exhaled breath have shown promise as biomarkers in idiopathic pulmonary fibrosis (IPF). We analysed breath from 57 people with IPF using thermal desorption-gas chromatography-mass spectrometry to identify VOCs related to lung function change over 12 months. A LASSO regression model selected 63 VOCs associated with relative change in forced vital capacity (8 with correlation coefficient (CC) ≥0.20 on Spearman's rank analysis), and 28 associated with relative change in diffusion capacity of the lung for carbon monoxide % predicted (12 with CC ≥0.20). Secondary analyses demonstrated a correlation between VOCs and baseline lung function parameters and association with survival. This study suggests that there may be a volatile signature of prognosis in IPF that merits further validation.
Source: Thorax
DOI: 10.1136/thorax-2024-222321
Authors: Conal Hayton, Waqar Ahmed, Dayle Terrington, Iain R White, Nazia Chaudhuri, Colm Leonard, Andrew M Wilson, Stephen J Fowler
Institutions: University of Manchester, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, University of East Anglia, University of Nova Gorica, University of Ulster, Western Health and Social Care Trust, Ulster University, Derry-Londonderry Campus
Language: English
Open Access status: green
OpenAlex ID: W4409972607
FWCI: 0.944
Cites: 10
Cited by: 4
Related to: 10