Year: 2025
Type: article
Abstract: The spread of a coronavirus infection can result in a pandemic, similar to the coronavirus disease 2019 pandemic. Such an infection also accounts for a considerable portion of common cold cases. Although coronavirus medicines are already available, alternative treatments are still required as the coronavirus can produce many variants. Matairesinol, a lignan family compound, is the constituent of cereals, such as rye. We used the human coronavirus OC43 to evaluate the antiviral activity of matairesinol. Matairesinol treatment interferes with coronavirus replication. This treatment decreases the expression of coronavirus protein and RNA as well as the number of coronavirus-induced plaque formations. Our experimental results collectively indicate that matairesinol treatment can potentially reduce coronavirus replication.
Source: Journal of Lifestyle Medicine
Authors: Kyoung Won Youn, Siyun Lee, Jaeyeon So, Chunghyeon Lee, Junsoo Park
Institution: Yonsei University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: Ministry of Education
Award: G3095016977
OpenAlex ID: W4409974116