Work

Association of Paternal Diabetes With Hemorrhagic Stroke in Bangladeshi Women: The MAGPIE Study

Year: 2025

Type: article

Abstract: ABSTRACT Background Hemorrhagic stroke (HS) accounts for ~10% of all first‐time strokes, with an increasing incidence in Asia and a scarcity of information available about sex‐related differences. This study investigates the independent predictors of HS among Bangladeshi women. Methods The Multidimensional Approach of Genotype and Phenotype in Stroke Etiology (MAGPIE) study is a Bangladeshi observational study that recruited nationwide HS patients between 2022 and 2024. We utilized univariate analysis to identify risk patterns in the data sets, whereas a multivariate logistic regression (LR) analysis identified the independent predictors of HS in women. Results We evaluated a total of 1080 hemorrhagic patients with female predominance (59.5%) and similar age of onset to males ( p = 0.38). Although males had significantly higher rates of hypertension ( p < 0.001), diabetes ( p = 0.008), chronic constipation ( p = 0.03), and systolic blood pressure ( p < 0.001), females were found to have significantly higher body mass index (23.1 ± 3.1 vs. 21.4 ± 2.9; p < 0.001) and paternal diabetes (9.6% vs. 4.8%; p = 0.004) compared to male. Further, the age‐adjusted multivariate LR model found paternal diabetes (OR 2.1, 95% CI 1.2–3.5, p = 0.007) as a potential independent predictor of HS in females compared to males. The area under the receiver operating characteristic (AUROC) curve of 0.67 (95% CI 0.63–0.70, p < 0.001) with 67.7% sensitivity and 58.2% specificity presents the goodness of fit of the model. Conclusion Bangladeshi women with a history of paternal diabetes have a 2.1‐fold heightened risk of HS than men.

Source: Health Science Reports

DOI: 10.1002/hsr2.70809

Authors: Md. Abdullah Yusuf, Redoy Ranjan, Dipannita Adhikary, Adneen Moureen, Maliha Hakim

Institutions: National Institute of Neurosciences & Hospital, Royal Holloway University of London, Bangladesh Medical University, United States Agency for International Development

Language: English

Topic: Intracerebral and Subarachnoid Hemorrhage Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,280