Work

Utility and Safety of Romiplostim as an Alternative to Platelet Transfusion for Neonates

Year: 2025

Type: article

Abstract: Thrombocytopenia is a common challenge in the neonatal intensive care unit, traditionally managed with platelet transfusions. However, transfusions are associated with significant risks, including increased mortality and neurodevelopmental impairment. This case series highlights the use of romiplostim, a thrombopoietin receptor agonist, in three neonates with thrombocytopenia. Each case demonstrated notable improvements in platelet counts without adverse events, reducing dependency on transfusions. These findings underscore romiplostim's potential as a safer alternative for managing neonatal thrombocytopenia. This report advocates for further research to explore romiplostim's efficacy and safety in this vulnerable population, emphasizing its promise in improving neonatal outcomes.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.31753

Authors: Rachel N. Zeno, Sara Awad, Harry Lesmana

Institutions: Cleveland Clinic Lerner College of Medicine, Case Western Reserve University

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,640