Work

The Diagnostic Landscape of Behavioral Variant Frontotemporal Dementia.

Year: 2025

Type: review

Abstract: The behavioral variant of frontotemporal dementia (bvFTD) is a progressive, neurodegenerative disorder, characterized by profound changes in personality, behavior, and social comportment. Diagnosis of bvFTD is challenging, and it is frequently misdiagnosed as an idiopathic psychiatric disorder (e.g., major depressive disorder, bipolar disorder) or another neurodegenerative disease (e.g., Alzheimer's disease dementia). The diagnostic challenge is exacerbated by a lack of reliable in vivo biological markers of disease pathology, which means that, at present, diagnosis relies largely on detailed behavioral and cognitive assessments. In this article, we discuss how clinical diagnostic criteria for bvFTD have evolved over the past three decades, and emphasize the diagnostic uncertainty that can arise when trying to distinguish between bvFTD and primary psychiatric disorders or other neurodegenerative diseases. In highlighting the strengths and limitations of the revised diagnostic criteria, and taking into account current diagnostic predicaments, we provide evidence-based recommendations for clinicians facing this diagnostic question. Finally, we touch on the importance of early (i.e., prodromal) diagnosis, and explain the utility of biomarkers for bvFTD diagnosis, with a nod to exciting research developments in this area.

Source: PubMed

Authors: Megan S Barker, Masood Manoochehri, Edward D Huey

Institutions: Brown University, Butler Hospital

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Mental Health

Awards: Neuroanatomical associations with the factor structure underlying neuropsychiatric symptoms in Alzheimer's disease, Using RDoC Negative and Positive Valence Paradigms to Investigate the Mechanisms of Neuropsychiatric Symptoms (NPS) in Alzheimer's Disease and Related Dementias, Genetic and neuroanatomical basis of neuropsychiatric symptoms in Alzheimer's disease in populations of diverse ancestry