Features of Invasive Aspergillosis Caused by Aspergillus flavus, France, 2012–2018
Year: 2025
Type: article
Study design: Observational Study
Abstract: Invasive aspergillosis (IA) caused by Aspergillus flavus remains poorly described. We retrospectively analyzed 54 cases of IA caused by A. flavus reported in France during 2012-2018. Among cases, underlying IA risk factors were malignancy, solid organ transplantation, and diabetes. Most (87%, 47/54) infections were localized, of which 33 were pleuropulmonary and 13 were ear-nose-throat (ENT) infection sites. Malignancy (70% [23/33]) and solid organ transplantation (21% [7/33]) were the main risk factors in localized pulmonary infections, and diabetes mellitus was associated with localized ENT involvement (61.5%, [8/13]). Fungal co-infections were frequent in pulmonary (36%, 12/33) but not ENT IA (0 cases). Antifungal monotherapy was prescribed in 45/50 (90%) cases, mainly voriconazole (67%, 30/45). All-cause 30-day case-fatality rates were 39.2% and 90-day rates were 47.1%, and rates varied according to risk factor, IA site, and fungal co-infections. Clinicians should remain vigilant for A. flavus and consider it in the differential diagnosis for IA.
Source: Emerging infectious diseases
Authors: Lise Bertin-Biasutto, Olivier Paccoud, Dea Garcia-Hermoso, Blandine Denis, Karine Boukris-Sitbon, Olivier Lortholary, Stéphane Bretagne, Maud Gits-Muselli, Raoul Herbrecht, Valérie Letscher-Bru, François Danion, Sophie Cassaing, Florent Morio, Céline Nourrisson, Marc Pihet, Milène Sasso, Guillaume Desoubeaux, Marie-Fleur Durieux, Julie Bonhomme, Elisabeth Chachaty, Taieb Chouaki, Nicole Desbois-Nogard, Alexandre Alanio, Jean-Pierre Gangneux, Fanny Lanternier
Institutions: Hôpital Necker-Enfants Malades, Inserm, Institut Pasteur, Université de Montpellier, Université Paris Cité, Université de Lille, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Louis, Institut de Cancérologie Strasbourg, Hôpitaux Universitaires de Strasbourg, Centre Hospitalier Universitaire de Toulouse, Hôpital Purpan, Hôpital Paule de Viguier, Hôpital de La Grave, Centre Hospitalier Universitaire de Nantes, Nantes Université, Centre Hospitalier Universitaire de Clermont-Ferrand, Centre Hospitalier Universitaire d'Angers, Centre Hospitalier Universitaire de Nîmes, Hôpital Bretonneau, Université de Limoges, Université de Caen Normandie, Institut Gustave Roussy, Centre Hospitalier Universitaire Amiens-Picardie, Centre Hospitalier Universitaire de Martinique, Hôpital Pontchaillou, Centre Hospitalier Universitaire de Rennes, Université de Rennes
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409990719