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Exposure to organophosphate flame retardants and phthalates alters neuronal activity and network development

Year: 2025
Type: article
Abstract: receptor, suggested that the effects of OPFR and phthalates were not endocrine-mediated. Further research is needed to elucidate the mechanisms underlying the different responses to acute and chronic exposure. Taken together, these results add to the evidence that TPhP and various phthalates illicit neurotoxic effects, some at low concentrations. These novel results should be considered in the risk assessment of these chemicals.
Source: Toxicology
DOI: 10.1016/j.tox.2025.154168
Authors: Lennart V.J. van Melis, Kyra N. Zimnik, Arjuna R. Persad, Teije Bak, Manon J.H. van Rossum, Regina G.D.M. van Kleef, J. Pepijn Wopken, Juliette Legler, Remco H.S. Westerink
Institution: Utrecht University
Language: English
Open Access status: hybrid
Estimated APC paid: $4,250
OpenAlex ID: W4409994589
FWCI: 2.43
Cites: 89
Cited by: 6
Related to: 10