Work

Early stage E-diagnosis of neurodegenerative diseases using label-free sensing of taurine biomarker by superconductive silver nano-ink: A miniaturized electro-device towards rapid neuro-analysis

Year: 2025

Type: article

Abstract: • A flexible electrochemical sensor was developed for the monitoring of taurine biomarker. • Silver conductive nano-ink was utilized for the construction of a novel working electrode. • A portable biodevice was developed for the -diagnosis of neurodegenerative diseases . • Labe-free sensor exhibited excellent sensitivity for detecting taurine biomarker in human plasma sample. In this research, a novel paper-based sensor was developed for the label-free sensing of taurine biomarker in human plasma sample. Silver superconductive nano-ink was used for construction of electrochemical device which show high conductivity (about 1800 µA). Sensor fabrication process was characterized by FESEM, EDAX, and AFM methods. The modified electrode was utilized as transducer for sensitive and selective detection of Taurine biomarker by cyclic voltammetry, square wave voltammetry, and differential pulse voltammetry techniques. The engineered sensor exhibited suitable sensitivity and specificity for detecting taurine with a linear range of 10 to 500 µM and a lower limit of quantification of 10 µM. The engineered low-cost device shows great potential for the in-situ biomedical analysis of neurodegenerative diseases using e-diagnosis technology.

Source: Sensors and Actuators Reports

DOI: 10.1016/j.snr.2025.100333

Authors: Rokhsareh Ebrahimi, Nasrin Shadjou, Mohammad Hasanzadeh, Farnaz Bahavarnia

Institutions: Tabriz University of Medical Sciences, Urmia University

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,430