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Protective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves on streptozotocin-induced testicular damage in rats

Year: 2025

Type: article

Abstract: Objective: This study investigated the protective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves on testicular cumulative reproductive function biomarkers in streptozotocin (STZ)-induced diabetic rats. Methods: Rats were induced with 40 mg/kg body weight (bwt) STZ intraperitoneally (i.p.), after which they were administered either a low (150 mg/kg bwt) or a high (300 mg/kg bwt) dose of flavonoid-rich extracts from H. sabdariffa leaves. Testicular redox biomarkers, reproductive hormone biomarkers, and relative gene expression levels of PDE-5 and iNOS were assessed. Additionally, histological data, glucose levels, G6PDH activity, and hydroxysteroid dehydrogenase activities (3β-HSD and 17β-HSD) were analyzed. Results: H. sabdariffa leaf extract was promising for restoring redox balance, normalizing reproductive hormone levels, modulating gene expression, and regulating various biochemical parameters related to testicular function. Conclusion: These data suggest a potential therapeutic role of H. sabdariffa leaves in mitigating the testicular dysfunction associated with diabetes.

Source: Phytomedicine Plus

DOI: 10.1016/j.phyplu.2025.100808

Authors: Basiru Olaitan Ajiboye, Courage Dele Famusiwa, John Adeolu Falode, Daniel Okwukwe Akojuru, Bamikole Tosin Owolabi, Adedeji A. Adejumo, Babatunji Emmanuel Oyinloye, Olawale Razaq Ajuwon, Oluwatosin Olalekan Ogedengbe, Oluwafemi Adeleke Ojo

Language: English

Topic: Hibiscus Plant Research Studies

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,590

OpenAlex ID: W4410014241

FWCI:

Cites: 73

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Related to: 10