Uremic toxins levels are associated with miR-223 in chronic kidney disease-associated anemia
Year: 2025
Type: article
Study design: Observational Study
Abstract: cells, a more physiological model for human erythropoiesis. Finally, serum levels of miR-223 correlated with representative uremic toxins, including IS, in patients with various stages of CKD, and also with endothelial dysfunction markers, indicating a link with vascular damage. These correlations varied according to erythropoietin treatment and dialysis. These findings suggest that miR-223 may play a role in the development of anemia in CKD. Further investigation into the involvement of miR-223 in erythropoiesis is needed for a better understanding of the mechanisms underlying anemia in CKD and the potential role of uremic toxins. Ultimately, this may open up new therapeutic possibilities for the management of anemia in CKD.
Source: Non-coding RNA Research
Institutions: Hématopoïèse et immunologie, Université de Picardie Jules Verne, Centre d’études des transformations des activités physiques et sportives, Université de Rouen Normandie, Centre Hospitalier Universitaire Amiens-Picardie, Norwegian University of Science and Technology, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Centre de recherche en Epidémiologie et Santé des Populations, Hôpital Ambroise-Paré, Association pour l'Utilisation du Rein Artificiel, Hôpital Paul-Brousse, Ghent University Hospital, Université Sorbonne Paris Nord, Laboratoire de Recherche Vasculaire Translationnelle
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,100
OpenAlex ID: W4410016631