Work

Comparative effects of glucosinolate-derived isothiocyanates from Camelina sativa seeds and sulforaphane on A549 lung cancer cells

Year: 2025

Type: article

Abstract: Plant-derived compounds, including isothiocyanates (ITCs), represent important sources of chemo-preventive and anticancer agents. ITCs naturally originate from glucosinolates (GLSs), the major phytochemicals in the plant family of Brassicaceae , a widely cultivated and economically important plant family. In this study, the well-known sulforaphane ITC (SFN) was compared with the ITC derived from the 10-(methylsulfinyl) decylglucosinolate, the most abundant GLS of Camelina sativa . In the experimental condition tested, SFN inhibits the viability of the lung cancer A549 cell line in a dose-dependent and time-dependent manner. Under the same experimental conditions, camelina ITC showed a higher selective cytotoxic activity compared to SFN, as well as higher in vitro antioxidant activity, highlighting it as a promising plant-derived molecule with protective effects against carcinogenesis. • CamITC shows stronger cytotoxic effects than SFN. • CamITC exhibits superior antioxidant activity, enhancing cellular protection. • CamITC is a promising bioactive molecule with cytotoxic and antioxidant properties.

Source: Journal of Agriculture and Food Research

DOI: 10.1016/j.jafr.2025.101982

Authors: Elena Ponzoni, Morena Gabriele, Andrea Cavallero, Roméo Arago Dougué Kentsop, Incoronata Galasso

Institutions: Istituto di Biologia e Biotecnologia Agraria, National Research Council

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,530