Work

Sex-specific hypothalamic neural projection activity drives caregiving in mice

Year: 2025

Type: article

Abstract: →PeFA projections reduced pup grooming in alloparental females but did not affect male caregiving, while projection stimulation reduced infant-directed aggression in males. Altogether, we show that this projection holds greater significance for female caregiving due to its heightened activity during natural behavior toward pups.

Source: Nature Communications

DOI: 10.1038/s41467-025-59352-7

Authors: Ilaria Carta, Tushar Arora, Stefano Lutzu, Giovanni Podda, Gaspar Nicolay Vera Ortega, Stephanie Rudolph, Anita E. Autry

Institution: Albert Einstein College of Medicine

Language: English

Topic: Neuroendocrine regulation and behavior

Subfield: Social Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,990

Funders: U.S. Department of Health and Human Services, Whitehall Foundation, Harvard University, National Institutes of Health, Intellectual and Developmental Disabilities Research Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1591889517, G17782488, G2232127272, Circuit, cellular, and molecular plasticity in hypothalamic microcircuits underlying flexible infant-directed behavior, Functional neuroanatomy of circuits governing parental behavior, G57236570, G8043626016, G9000009062, SUPPORT FOR THE ROSE F KENNEDY IDDRC P50

OpenAlex ID: W4410019961

FWCI: 6.58

Cites: 56

Cited by: 6

Related to: 10