Cardio-oncology Outcomes in Ultrasound-assisted Versus Standard Catheter-directed Thrombolysis for Acute Pulmonary Embolus
Year: 2025
Type: article
Abstract: Acute pulmonary embolism (PE) is the third leading cause of cardiovascular death, claiming the lives of over 100,000 people annually in the United States alone.1 Systemic thrombolysis (ST) remains the traditional treatment for high-risk PE, although its effectiveness in reaching the clot can be limited, and its safety can be significantly challenged by major bleeding (including up to 1.5% intracranial bleeding). Catheter-directed therapy (CDT) is a newer and more targeted technique in which thrombolytics are directly applied onto the thrombus of intermediate and high-risk PE using standard catheter-directed thrombolysis (SCDT) and ultrasound-assisted thrombolysis (USAT), with the latter consisting of high-frequency acoustics added to SCDT to improve thrombolytic penetration for greater dissociation of fibrin strands.
Authors: Dominique J. Monlezun, Dinu Balanescu, Teodora Donisan, Arashk Motiei, Brenden S. Ingraham, Keir MacKay, Hyeon-Ju Ali, Kevin Honan, Abdelrahman Ali, Salman Arain, Konstantinos Charitakis, Mehmet Cilingiroglu, Konstantinos Dean Boudoulas, Jaime Caballero, Konstantinos Marmagkiolis, Cezar Iliescu
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,400
OpenAlex ID: W4410025820