Year: 2025
Type: article
Abstract: The content examines the therapeutic potential of Hypnea spinella, a species of red algae, in managing Alzheimer’s disease (AD). AD is the most prevalent cause of dementia globally, characterized by memory loss, cognitive decline, and behavioural changes, primarily affecting older adults. Despite extensive research into its genetic, environmental, and pathological underpinnings, effective disease-modifying treatments remain elusive. This study explores the bioactive compounds of Hypnea spinella, including sulfated polysaccharides, polyphenols, antioxidants, and other metabolites. These compounds exhibit neuroprotective, anti-inflammatory, and antioxidant properties that could target key mechanisms of AD pathology, such as amyloid plaque accumulation, tau protein dysfunction, oxidative stress, and neuroinflammation. The potential of these bioactive compounds to mitigate neurodegeneration and enhance cognitive health is highlighted. The document further provides an overview of AD’s epidemiology, genetic risk factors, pathophysiology, and progression through its clinical stages. Current treatment strategies primarily focus on symptomatic relief rather than halting or reversing the disease process. Given the increasing global burden of AD and the limitations of existing treatments, Hypnea spinella emerges as a promising natural resource for developing innovative therapies. This research underscores the need for further studies to validate the efficacy and safety of its bioactive compounds for Alzheimer’s disease management.
Authors: Athulya Dileep T.P, Afra K.V, Ajna P.M, Anamika Anil, Ayisha Rifa P, E. Tamil Jyothi, G. Babu
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410029125