Incidence and prevalence of granulomatosis with polyangiitis in Sweden, 2006–2019, a register-based study
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate incidence and prevalence of granulomatosis with polyangiitis (GPA) in Sweden nationwide between 1 January 2006 until 31 December 2019 in a register-based study including the entire Swedish population. METHOD: In the population-based National Patient Register (NPR) we identified patients with incident and prevalent GPA during the period 2006-2019. Age- and sex standardized annual incidence and crude period prevalence were estimated. Results were stratified on age, sex, and season. RESULTS: We identified 2013 individuals with incident GPA during the study period. Median age was 63 years (IQR 51-72) and 46 % were women. The mean standardized incidence was 1.9 per 100,000 person-years (95 % CI 1.8-2.0), with a slightly higher incidence in men 2.0 (95 % CI 1.9-2.2) than in women 1.7 (95 % CI 1.6-1.8). We noted the highest incidence in the group aged 70-79, 4.1 (95 % 3.7-4.5). The annual incidence remained stable over the study period range 1.7-2.0. We could not find any seasonal variation in incidence. The point prevalence on December 31st, 2019, was 25.4 per 100,000 (95 % CI 24.3-26.5) based on the 2132 individuals we identified as prevalent. The period prevalence increased from 18.7 per 100,000 (95 % CI 17.8-19.1) in 2006-2010 to 23.9 per 100,000 (95 % CI 22.8-25.0) in 2016-2019. CONCLUSION: Our estimates show that incidence of GPA has been stable over the period 2006-2019 in Sweden which are in line with published data from southern Sweden. The prevalence increased during the study period which could be due to improvement in treatment leading to an increased survival.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,370
OpenAlex ID: W4410029878