Work

Thyroid Transcription Factor-1 (TTF-1) expression in lungs metastatic adenocarcinoma from sigmoid primary: a diagnostic pitfall in a 63-year-old man

Year: 2025

Type: article

Abstract: Thyroid transcription factor 1 (TTF-1), a very sensitive and specific marker for primary lung adenocarcinoma, has been used as a diagnostic marker for distinguishing primary pulmonary neoplasm from adeno-carcinomatous metastasis from other sites, such as the colorectal region. In a few cases, metastases have also been shown to express TTF-1. Here, we present the case of a 63-year-old man who developed metastases to the right lung from metastatic sigmoid adenocarcinoma. The pulmonary secondary lesion was strongly positive for TTF-1. There is a paucity of existing English scientific literature to prove the non-specific nature of TTF-1 expression. This is the first documented case of its kind from Pakistan and probably the sixth case in the world. The versatile expression of IHC (Immunohistochemistry) markers influences the nature, progression and management of malignancies. Hence, histopathologists need to be aware of this extremely rare occurrence.

Source: Journal of the Pakistan Medical Association

DOI: 10.47391/jpma.11556

Authors: Babar Yasin, Muhammad Awais Ahmad, Haseeb Mehmood Qadri, Nauman Hakeem

Institutions: Akhtar Saeed Medical and Dental College, Lahore General Hospital

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650