Work

IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

Year: 2025

Type: article

Abstract: . These findings support replication stress as the dominant consequence of IMPDH2 inhibition in MCC and, when combined with ATR inhibition, indicate a potential therapeutic strategy.

Source: iScience

DOI: 10.1016/j.isci.2025.112567

Authors: Julia L. Schnabel, Thomas C. Frost, Adam C. Wang, Varsha Ananthapadmanabhan, Satvik Gurram, Kara M. Soroko, Prafulla C. Gokhale, James A. DeCaprio

Institutions: Harvard University, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Northeastern University, Dana-Farber/Harvard Cancer Center

Language: English

Topic: Polyomavirus and related diseases

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Dana Foundation, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, National Institutes of Health, U.S. Public Health Service, National Cancer Institute

Awards: Human Cancer Suppressor Functions of Protein Phosphatase 2A, G1547207268, G1864025506, G3154927976, G6381868615, Identification of Novel Oncogenic Signaling Pathways using Viral Perturbations, CaNCURE: Cancer Nanomedicine Co-ops for Undergraduate Research Experiences

OpenAlex ID: W4410032213

FWCI: 1.085

Cites: 46

Cited by: 3

Related to: 10