Work

Evaluation of the safety of short-term follow-up CT for the management of consolidation in lung cancer screening

Year: 2025

Type: article

Abstract: OBJECTIVES: Focal consolidation on CT may be inflammatory or malignant, and PET-CT imaging is rarely discriminatory. Furthermore, consolidation may demonstrate spontaneous resolution obviating the need for PET-CT imaging. This retrospective study sought to assess the safety and cost-effectiveness of short-interval 6-week follow-up CT for consolidation in a lung cancer screening programme. METHODS: Between January 2019 and January 2024, participants in a regional lung cancer screening programme with focal indeterminate consolidation underwent a 6-week repeat CT rather than immediate PET-CT and invasive investigation. The proportion of participants with non-resolving consolidation, the risk of malignancy in consolidation at a 6-week follow-up, and the risk of upstaging over a 6-week delay were determined. Cost savings were estimated from National Health Service reference costs. RESULTS: In 10,247 CT studies, focal indeterminate consolidation was detected in 113 participants (1.1%) (mean age 68 years, range 55-76, 65 males). Consolidation spontaneously resolved at 6 weeks in 63/110 (57%) who attended follow-up; 14/110 (12.7%) participants had malignancy; no patients upstaged during follow-up. An estimated cost saving of £47,600/10,000 screening CTs performed might be obtained through a conservative approach of short-term interval CT, rather than immediate PET-CT and further investigation. CONCLUSION: Early repeat CT avoids PET-CT in more than half of patients with consolidation and can be utilised to reduce over-investigation of screen-detected consolidation, which may demonstrate spontaneous resolution. KEY POINTS: Question Is short-term interval follow-up CT in lung cancer screening a safe and cost-effective approach to managing indeterminate (inflammatory or malignant) consolidation? Findings Short-interval CT imaging demonstrates spontaneous resolution of consolidation in over 50% participants in this study, whilst persistent consolidation has a high likelihood of malignancy. Clinical relevance Short-interval CT did not result in upstaging of malignancy and therefore can be considered a safe strategy to prevent the over-investigation of screen-detected consolidation, supporting recent European and American screening recommendations.

Source: European Radiology

DOI: 10.1007/s00330-025-11609-x