Comparison of Patient Adherence and Treatment Response in Patients with Chronic Viral Hepatitis: Results of a 48-Week Observational Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objectives: Viral hepatitis is one of the significant health problems in the world.The main purpose of treatment is virological eradication.There are many factors that determine treatment response.The most important factor that can be affected is treatment adherence.In our study, we aimed to compare compliance with treatment response, which is one of the factors that can be affected in chronic viral hepatitis patients.We highlight that this element should be considered in treatment failures, especially in chronic diseases that require long-term treatment.Materials and Methods: Chronic hepatitis patients over 18 years of age and under 65 years of age, who were neither coinfected with Human immunodeficiency virusnor pregnant, were prospectively analyzed after receiving ethics committee approval.Treatment adherence was defined as taking the prescribed medication in the required number of doses and for the required duration.Drug count and questionnaires were used in the compliance assessment.Patients' compliance and patients' 12, 24, 36, and 48th-week virological responses were compared.Results: Seventy-six patients were included in the study.Sixty point five percent of patients had chronic hepatitis B, and 39.5% had chronic hepatitis C. According to the drug count data, it was determined that 83.9% of the patients did not take their treatment during at least one visit.At the end of the treatment (48th-week follow-up), 89.4% of all chronic hepatitis patients were compliant and 92.6% of the compliant patients responded to the treatment.Five out of eight incompatible patients, accounting for 62.5%, were able to respond to the treatment.Response rates of compliant and Ad dress for Cor res pon den
Source: Viral Hepatitis Journal
Institutions: Acıbadem University, Acıbadem University Atakent Hospital
Language: English
Subfield: Family Practice
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410035309