Engineering a Tumor‐Acidity‐Responsive PEG‐Sheddable Nanoassembly for Combating Drug Resistance
Year: 2025
Type: article
Abstract: This study presents a simple strategy to develop a tumor‐acidity responsive core‐crosslinked micellar nanoassembly capable of delivering multiple drugs to combat drug resistance. Paclitaxel (PTX) nanocrystals are prepared using D‐α‐tocopherol polyethylene glycol 1000 succinate (TPGS) as an emulsifier and cross‐linked with poly(β‐cyclodextrin) (PCD) to form the core. An acid‐labile prodrug, poly(ethylene glycol)‐doxorubicin (mPEG‐DOX), is utilized as the shell, forming a core‐shell nanoassembly (CSNA) via supramolecular interactions. The CSNA demonstrated high stability in aqueous and serum environments, with triggered shell‐detachment in response to tumor acidity. The nanomedicine exhibited superior inhibition of drug‐resistant cancer cell line MCF‐7/ADR compared to DOX or PTX alone, offering potential to overcome drug resistance in chemotherapy.
Authors: Jin Xie, Mengxue Zhou, Hongyu Ren, Rui Dou, Jiayu Zhang, Yi Hu, Jun Ouyang, Jun Chen
Institutions: Chinese Academy of Sciences, Institute of High Energy Physics, First Affiliated Hospital of Zhengzhou University, University of Chinese Academy of Sciences, Southern Medical University, Chinese Academy of Agricultural Sciences, Tea Research Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4410038518