Year: 2025
Type: article
Study design: Observational Study
Abstract: Aims We aimed to investigate the potential association between relative fat mass (RFM) and colorectal cancer (CRC). Design and methods Data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2020 were analyzed. Associations between RFM and CRC were analyzed using multiple logistic regression. Smoothed curve fitting was performed to conduct the association by sex. The stability of associations was assessed using subgroup analyses and interaction tests. Results Overall, 52,281 participants over the age of 20 years were enrolled. The fully adjusted model observed a positive association between RFM and CRC, with one-unit increases in RFM linked to a 3% greater prevalence of CRC (OR = 1.03, 95%CI: 1.01, 1.06). A linear positive association was identified between RFM and CRC in male subjects, while a non-linear relationship was observed in females, with an inflection point at 42. Subgroup analysis revealed that age significantly modified the relationship between RFM and CRC (P for interaction = 0.0085). Conclusion RFM is strongly associated with CRC prevalence in US adults. Further large-scale prospective investigations are warranted to for verification.
Source: Frontiers in Nutrition
Authors: Yaping Wang, Shilong Song, Lu Zhang, Jingjing Zhang
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4410040768