Work

DNA virus tropism in healthy dental pulp: an in-situ reservoir site for torque teno virus and parvovirus B19

Year: 2025

Type: article

Abstract: Background: The presence of viruses in healthy teeth has not been extensively studied, although some viral traces have been detected in both healthy and diseased dental pulps in previous studies focusing primarily on a single species. The aim of this study is to clarify the persistence of DNA viruses in dental tissues and their impact on tissue composition. Materials and Methods: = 17) was assessed via quantitative PCR to detect human parvovirus B19 (B19V), torque teno virus (TTV) and nine human herpesviruses. Also, H&E-stained tissue sections of the samples were analyzed for any potential inflammatory process. RNAscope in-situ hybridization was performed for B19V, TTV and HHV7 subsequently. Results: = 1) in dental pulps with no signs of cytopathic effect, inflammatory cell accumulations or necrosis. RNAscope in-situ hybridization confirmed the presence of B19V and TTV in non-inflamed pulp tissue. Conclusions: These findings emphasized that even in the absence of a disease evaluated by histology, dental pulp can harbor DNA viruses and be an anatomical site of virus tropism, suggesting viral persistence rather than direct pathogenic activity.

Source: Journal of Oral Microbiology

DOI: 10.1080/20002297.2025.2499924

Authors: O. I. Mielonen, S. Hänninen, J. Willberg, T. Salo, M. Mauramo

Institutions: University of Helsinki, Helsinki University Hospital, University of Turku

Language: English

Topic: Parvovirus B19 Infection Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,428