Work

Anti-SOX1 antibody-associated paraneoplastic cerebellar degeneration without detectable tumor

Year: 2025

Type: article

Abstract: A 56-year-old male presented with complaints of insidious onset difficulty in speech and head tremors for 2 years and imbalance while walking for 1 year. He did not have autonomic dysfunction and had a negative family history. The cerebrospinal fluid examination was normal and the workup for autoimmune disorders was negative. Brain magnetic resonance imaging showed mild superior cerebellar atrophy. The serum paraneoplastic antibody panel showed anti-Sry-like high mobility group box (SOX1) antibodies positivity. He was treated with steroids and steroid-sparing immunosuppressants resulting in mild improvement. Extensive workup for underlying malignancy was negative. Our case illustrates a small subset of individuals with anti-SOX1 antibody positivity who also exhibit neurological symptoms indicative of paraneoplastic cerebellar degeneration without having any underlying tumor and responded to immunotherapy.

Source: Journal of Neurosciences in Rural Practice

DOI: 10.25259/jnrp_18_2025

Authors: Farsana Mustafa, Rajesh Kumar Singh, Animesh Das, Deepti Vibha, Manjari Tripathi

Institution: All India Institute of Medical Sciences

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $125