Figure 4 from High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
Year: 2025
Type: other
Abstract: Classification of mCRPC tissue biopsy samples and low-purity CTC samples into the high-purity CTC phenotypes recapitulates survival differences. A, Classification of mCRPC tissue biopsy samples (n = 203) with a k-nearest neighbor (KNN) classifier trained on the high-purity CTC sample phenotypes recapitulates the differences in survival outcome seen between the four CTC phenotypes. B, Low CTC burden (Low_CTC) samples with at least minimal epithelial gene expression defined as an expression sum of four epithelial markers (EpCAM, KRT8, KRT18, and KRT19) of >10 transcripts per million (n = 30) were reclassified using the same KNN classifier as in A. Survival differences between the reclassified Low_CTC samples recapitulates the differences in survival outcome seen between the four CTC phenotypes in the high-purity CTC samples.
Authors: Marina N. Sharifi, Jamie M. Sperger, Amy K. Taylor, Katharine E. Tippins, Shannon R. Reese, Viridiana Carreno, Katherine R. Kaufmann, Alex H. Chang, Luke A. Nunamaker, Charlotte Linebarger, Leilani Mora-Rodriguez, Jennifer L. Schehr, Hannah M. Krause, Kyle T. Helzer, Matthew L. Bootsma, Grace C. Blitzer, John M. Floberg, Christos E. Kyriakopoulos, Hamid Emamekhoo, Elisabeth I. Heath, Meghan Wells, Scott T. Tagawa, Martin Sjöström, Atish D. Choudhury, Menggang Yu, Andrew J. Armstrong, Dana E. Rathkopf, Himisha Beltran, Peter S. Nelson, Felix Y. Feng, Scott M. Dehm, David Kosoff, Xiao X. Wei, Rana R. McKay, Shuang G. Zhao, Joshua M. Lang
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4410047336