Figure 5 from High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
Year: 2025
Type: other
Abstract: Luminal-B CTC phenotype and persistent PSMA expression are associated with poor response to 177Lu–PSMA-617. A, Clinical benefit rate (the best radiographic response of stable disease, partial response, or complete response) for 177Lu–PSMA-617 in patients with favorable pretreatment CTC phenotypes (Low_CTC, LP, and LumA) vs. pretreatment LumB phenotype. B, Proportion of pretreatment LumB vs. favorable CTC phenotypes for patients with and without 177Lu–PSMA-617 early progression (disease progression within the first three cycles/18 weeks of treatment). C, Baseline CTC FOLH1 (PSMA) gene expression for LumB (n = 8) vs. favorable CTC phenotypes (n = 29). Kaplan–Meier plot for (D) radiographic progression-free survival (rPFS) and (E) OS illustrates decreased rPFS and OS after starting 177Lu–PSMA-617 for patients with the pretreatment LumB CTC phenotype. F, Longitudinal evaluation of consensus AR/luminal and neuroendocrine pathway scores during 177Lu–PSMA-617 treatment. Patient 818 (left) represents an example of a patient with early progression on 177Lu–PSMA-617 who demonstrated a rapid increase in NE score and decrease in AR score on treatment. Patient 978 (right) illustrates a patient with a longer duration of response who also shows an increased NE score and decreased AR score at the time of disease progression.
Authors: Marina N. Sharifi, Jamie M. Sperger, Amy K. Taylor, Katharine E. Tippins, Shannon R. Reese, Viridiana Carreno, Katherine R. Kaufmann, Alex H. Chang, Luke A. Nunamaker, Charlotte Linebarger, Leilani Mora-Rodriguez, Jennifer L. Schehr, Hannah M. Krause, Kyle T. Helzer, Matthew L. Bootsma, Grace C. Blitzer, John M. Floberg, Christos E. Kyriakopoulos, Hamid Emamekhoo, Elisabeth I. Heath, Meghan Wells, Scott T. Tagawa, Martin Sjöström, Atish D. Choudhury, Menggang Yu, Andrew J. Armstrong, Dana E. Rathkopf, Himisha Beltran, Peter S. Nelson, Felix Y. Feng, Scott M. Dehm, David Kosoff, Xiao X. Wei, Rana R. McKay, Shuang G. Zhao, Joshua M. Lang
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4410047380