Figure 3 from Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody–Drug Conjugate TAK-500
Year: 2025
Type: other
Abstract: mTAK-500 shows dose-dependent efficacy and induction of cytokine release in MC38 tumor–bearing mouse models. A, Antitumor effect of mTAK-500 in C57BL/6 mice bearing MC38 tumors. Data shown represent the MTVs from eight mice per group. B, Cytokine response in the plasma of MC38 tumor–bearing mice treated with mTAK-500 at 6 hours after treatment. Blue dots represent vehicle-treated animals; black dots represent mTAK-500–treated animals. Data shown represent the mean from three mice per group. For all panels, experiment was performed at least twice with consistent results between independent replicates. For all panels, error bars indicate SEM. P values relative to vehicle control: *, ≤0.05; ** ≤0.01; ***, <0.00001.
Authors: Vicky A. Appleman, Atsushi Matsuda, Michelle L. Ganno, Dong Mei Zhang, Emily Rosentrater, Angel E. Maldonado Lopez, Angelo Porciuncula, Tiquella Hatten, Camilla L. Christensen, Samantha A. Merrigan, Hong Myung Lee, Min Young Lee, Charlotte I. Wang, Linlin Dong, Jian Huang, Natasha Iartchouk, Jianing Wang, He Xu, Tomoki Yoneyama, Konstantin I. Piatkov, Satyajeet Haridas, Carole E. Harbison, Richard C. Gregory, Alexander Parent, Neil Lineberry, Chris Arendt, Kurt A. Schalper, Adnan O. Abu-Yousif
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4410047693