Figure 3 from High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
Year: 2025
Type: other
Abstract: Luminal-B CTC phenotype is associated with poor prognosis and adverse clinical features. A, Serum PSA (ng/mL) at the time of CTC collection in the survival analysis subset (Low_CTC, n = 63; Low_prolif, n = 12; LumA, n = 21; LumB, n = 18; and NE, n = 3). B, Proportion of samples in each CTC transcriptional phenotype for each disease category in the survival analysis subset (mCSPC, n = 20; mCRPC, n = 93; and NEPC, n = 4) is shown. C, Kaplan–Meier plot of the OS from the time of the first CTC collection for each patient (n = 117) by CTC transcriptional phenotype at the first CTC collection. Median survival, and HR and log-rank P value relative to low CTC burden (Low_CTC) phenotype are shown in the inset. Risk table is shown below. D, Multivariate analysis of the CTC phenotype clustersgroups demonstrates that LumB remains a poor prognostic factor after adjusting for adverse clinical features. E, Distribution of CTC transcriptional phenotypes by metastatic sites involved at the time of the first CTC collection including lymph node only (LN only, n = 7), bone ± lymph node (bone ± LN, n = 64), at least one non-liver soft-tissue site (non-liver visceral, n = 14), and at least one liver site (liver, n = 20).
Authors: Marina N. Sharifi, Jamie M. Sperger, Amy K. Taylor, Katharine E. Tippins, Shannon R. Reese, Viridiana Carreno, Katherine R. Kaufmann, Alex H. Chang, Luke A. Nunamaker, Charlotte Linebarger, Leilani Mora-Rodriguez, Jennifer L. Schehr, Hannah M. Krause, Kyle T. Helzer, Matthew L. Bootsma, Grace C. Blitzer, John M. Floberg, Christos E. Kyriakopoulos, Hamid Emamekhoo, Elisabeth I. Heath, Meghan Wells, Scott T. Tagawa, Martin Sjöström, Atish D. Choudhury, Menggang Yu, Andrew J. Armstrong, Dana E. Rathkopf, Himisha Beltran, Peter S. Nelson, Felix Y. Feng, Scott M. Dehm, David Kosoff, Xiao X. Wei, Rana R. McKay, Shuang G. Zhao, Joshua M. Lang
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4410047740