Work

A Regioselective Ruthenium‐Catalyzed Oxidative C–H Alkenylation of 2‐Aryl‐4H‐Benzo[d][1,3] Oxazin‐4‐Ones

Year: 2025

Type: article

Abstract: ABSTRACT 2‐Aryl‐4H‐benzo[d][1,3]oxazin‐4‐one derivatives can be directly alkenylated with alkyl acrylates using a facile Ru (II)‐catalyzed process; using Cu (OAc)2•H2O as an oxidizer through formation of a pentagon cyclic complex of imine‐Ru (II) for C–H activation is described. The unique catalytic reaction is well matched with miscellaneous olefins such as vinyl ketones, acrylonitrile, and acrylates. The aryl rings bearing electronically diverse substituents tolerated the reaction conditions to provide ortho‐alkenylation products in high regioselectivities and admissible yields.

Source: Applied Organometallic Chemistry

DOI: 10.1002/aoc.70163

Authors: Sepideh Bahrami Nasab, Seyed Iman Alavioon

Institutions: University of Tehran, National Nutrition and Food Technology Research Institute, Shahid Beheshti University, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Science Foundation, Iran National Science Foundation, University of Tehran, Shahid Beheshti University of Medical Sciences

Award: G8483324049