Work

Qtc Interval Prolongation: Role of Polypharmacy, Drug Interaction and Considerations for Clinical Practice

Year: 2025

Type: article

Abstract: Highlights Acquired long QT syndrome is a rare disease, but the frequency of QTc prolongation increases with polypragmasia. Abstract Acquired long QT syndrome is a rare condition. However, the prevalence of prolonged QTc interval increases among patients with polypharmacy. The risk of both QTc interval prolongation and torsades de pointes (TdP) tachycardia escalates exponentially with the concomitant use of multiple QTc-prolonging drugs. This article explores the underlying mechanisms of the condition and methods to mitigate the risk of potentially fatal arrhythmias.

Source: Complex Issues of Cardiovascular Diseases

DOI: 10.17802/2306-1278-2025-14-2-127-135

Authors: Vladimir P. Kuzmin, Irina A. Zolotovskaya, Svetlana P. Krivova, Rais K. Khayretdinov, Violetta A. Rodionova, Olesya A. Rubanenko, Igor L. Davydkin

Institutions: Samara State Medical University, Samara Regional Clinical Oncology Center

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4410075238

FWCI: 0.635

Cites: 36

Cited by: 1

Related to: 10