Work

The influence of sleep duration on patients with coronary artery disease: a four-year observational study

Year: 2025

Type: article

Abstract: Background: Coronary artery disease (CAD) is highly prevalent and fatal worldwide. In China, particularly in the southwest region, the association between CAD and sleep duration remains insufficiently understood. This study aims to investigate outcomes among CAD patients with varying sleep duration. Methods: In a Southwest Chinese cohort, patients with CAD were categorized into three sleep duration groups: <6 hours, 6-8 hours, and >8 hours. Over a four-year follow-up, the endpoint including new-onset myocardial infarction and CAD-related deaths was recorded. The Fine-Gray model was employed to evaluate the estimated marginal occurrence probability of the target event. Additionally, Kaplan-Meier estimation and Cox regression analysis were conducted to further investigate the association between sleep duration and outcomes. Results: =0.006). This trend was consistently observed in both the Fine-Gray model and subgroup analyses. Conclusions: Both short (<6 hours/day) and long (>8 hours/day) sleep duration were linked to an elevated risk of cardiac mortality among CAD patients in Southwest China. Short sleep duration was also found to be associated with high myocardial infarction risk.

Source: Frontiers in Endocrinology

DOI: 10.3389/fendo.2025.1555880