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Sex-specific cardiac electrophysiological remodeling influences the susceptibility to arrhythmias in elderly rats

Year: 2025

Type: article

Abstract: Aged heart is more prone to develop cardiovascular diseases including arrhythmias. The age-related electrical remodeling of the heart results in specific electrophysiological alterations in male and female rats. Males could experience more challenging adaptations as they age. They show prolongations of atrial and ventricular activation, ventricular repolarization, and refractoriness. Aged females display alterations in ventricular activation. Arrhythmias are more likely to occur in aged animals with males being more susceptible to spontaneous and induced arrhythmias.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00199.2025

Authors: Rosario Statello, Giovanna Pelà, Roberta Maestri, Fabio Leonardi, Aderville Cabassi, Ignazio Verzicco, Alessandra Rossi, Luca Carnevali, Paolo Pastori, Domenico Corradi, Michele Miragoli, Emilio Macchi, Stefano Rossi

Institutions: University of Parma, IRCCS Humanitas Research Hospital

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4410079862

FWCI: 0.635

Cites: 55

Cited by: 1

Related to: 10