Work

Application of the ENCALS predictive survival model in assessing the effect of the 24/44 inclusion criteria in FORTITUDE-ALS

Year: 2025

Type: article

Abstract: FORTITUDE-ALS was a study evaluating reldesemtiv in people living with ALS. Post-hoc analysis identified larger treatment effects in those with symptom onset ≤24 months and baseline ALSFRS-R ≤ 44 (24/44 criteria). Using the ENCALS risk score (RS), we analyzed how the 24/44 criteria changed the eligible population. Of the 272 participants meeting the 24/44 criteria, 73% had very short to intermediate RS compared to 18% not meeting the criteria. Though the 24/44 criteria enriched the FORTITUDE-ALS population with rapidly progressing patients, they did not completely exclude all patients with a very long predicted survival.

Source: Journal of Neuromuscular Diseases

DOI: 10.1177/22143602251336058

Authors: Tyrell Simkins (lead), Jeremy M Shefner, Stuart Kupfer, Fady I Malik, Lisa Meng, Stacy A Rudnicki, Jenny Wei, Ruben PA van Eijk

Institutions: Cytokinetics (United States), Creighton University, Barrow Neurological Institute, University of Arizona, University Medical Center Utrecht

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4410081540

FWCI:

Cites: 8

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Related to: 10