Work

Proton Beam Therapy for the Treatment of Recurrent Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Case Report

Year: 2025

Type: article

Abstract: Human papillomavirus-related multiphenotypic sinonasal carcinoma (HMSC) is a rare sinonasal tract tumor. Although HMSC has a favorable prognosis, patients tend to experience local recurrence after the initial therapy; therefore, careful follow-up is required after surgical dissection. Proton beam therapy is one of the therapeutic modalities used to treat sinonasal cancer. This is the first report on the use of proton beam therapy for definitive irradiation in HMSC. Herein, we report the case of a 30-year-old woman with HMSC. The right nasal tumor was surgically resected by endoscopy, and HMSC was diagnosed using pathology. The diagnosis of HMSC was made. Nine months after surgery, a recurrent invasive tumor was found in the right nasal cavity, and surgical treatment was not feasible. Proton beam therapy was administered to the recurrent lesion, resulting in radiographic complete response maintained for nine months. This case suggests that postoperative recurrence must be noted and that proton beam therapy is an option to treat locally advanced lesions.

Source: Cureus

DOI: 10.7759/cureus.83539

Authors: Ken Matsumoto, Shiro Akahani

Institution: Kansai Rosai Hospital

Language: English

Topic: Head and Neck Surgical Oncology

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410081813