Work

Stereoselective Preparation of (4S)-1-Methyl-4-propyl-L-proline Commencing from (cis)-4-Hydroxy-L-proline

Year: 2025

Type: article

Abstract: We present a recipe for the stereoselective conversion of commercial (cis)-4-hydroxy-L-proline into (4S)-1-methyl-4-propyl-L-proline, an analog of the amino acid fragment found in the clinically used antibacterial antibiotic lincomycin. The single-crystal X-ray diffraction analysis of the final target’s hydrochloride salt confirms its identity and absolute stereochemistry.

Source: Molbank

DOI: 10.3390/m2003

Authors: Gour Mandal, Shifali Choudhary, Steven Kelley, Shyam Sathyamoorthi

Institutions: University of Kansas, University of Missouri

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $603

Funders: National Institutes of Health, National Institute of General Medical Sciences