Work

Causal relationship of garlic or onion with gastric cancer based on a Mendelian randomization study

Year: 2025

Type: article

Abstract: In observational studies, it has been known that garlic or onions have a negative causal relationship with gastric cancer (GC). In this study, we aim to explore the negative causal relationship between garlic or onion and GC through Mendelian randomization (MR) analysis. The instrumental variable selection for MR analysis is single nucleotide polymorphisms associated with garlic or onion, mainly using the inverse variance weighted method, combined with MR Egger, weighted media, simple mode, and weighted modes to evaluate their causal impact on GC. In addition, sensitivity analysis such as Cochran Q test, pleiotropy test, and leave-one-out method were used to evaluate the robustness of the impact of these single nucleotide polymorphisms on GC. The inverse variance weighted method showed a negative correlation between garlic and GC risk (odds ratio = 0.70; 95% confidence interval 0.49-0.99; P = .046), while there was no relationship between onion and GC, and the sensitivity analysis results showed robustness. The current study has revealed that garlic may be a factor in reducing the risk of GC, providing a strategy for preventing and treating GC.

Source: Medicine

DOI: 10.1097/md.0000000000041639

Authors: Zhaoyin Wang, Pengfei Liu, Jingbin Wang, Pengli Ma, Xinyao Liu

Institutions: Heilongjiang University of Chinese Medicine, Guangzhou University of Chinese Medicine

Language: English

Topic: Garlic and Onion Studies

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950